In .NET 4.6.1, Activator.CreateInstance with assembly names loads the type in the current AppDomain by default. For cross-domain instantiation, use AppDomain.CreateInstance .
In the .NET 4.6.1 ecosystem—which was heavily used for ASP.NET MVC 5, Web API 2, and WPF— Activator was the silent engine behind the magic. activators dotnet 4.6.1
In the Windows environment, .NET 4.6.1 relies on activation components to manage how services start up in response to incoming messages. In .NET 4.6.1
public static ObjectActivator CreateActivator(ConstructorInfo ctor) Web API 2