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As computational biology advances, the "Replacement" leg of the 3 Rs is accelerating. Organs-on-chips and sophisticated computer models are replacing animal testing. If we can replace 99% of animal use with non-sentient alternatives, the debate shrinks to a smaller, more contentious core.

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Leo watched Barnaby collapse into a patch of clover, panting happily. He realized that while he couldn't change the beagle's past, he could protect his welfare every day while speaking up for the rights of all animals to ensure a kinder future. As computational biology advances, the "Replacement" leg of

The gold standard for welfare is the originally developed for livestock but now applied across the board: As computational biology advances