: While named "2010," this runtime is essential for running Office solutions created in Visual Studio 2010, 2012, 2013, 2015, and newer versions up to 2022. Microsoft Learn Architecture & Installation x64 vs. x86 version is specifically for computers running 64-bit editions of Microsoft Office
Conversely, if you have 32-bit Office installed on a 64-bit Windows system, you would actually need the x86 version of the runtime. System Requirements and Prerequisites microsoft visual studio 2010 tools for office runtime -x64-
Visual Studio Tools for Office runtime overview - Microsoft Learn : While named "2010," this runtime is essential
The (64-bit) version of the runtime is specifically required when you are running a 64-bit edition of Microsoft Office . Required for running solutions in Office 2013, 2016,
: It has a "smart" loader. If you install it and a required .NET Framework extension is missing, the runtime will automatically wait and install it later when the requirements are finally met.
Required for running solutions in Office 2013, 2016, 2019, 2021, and Office 365 Installation & Troubleshooting